3D Tissue Imaging

Clearing Technique Compatibility and Comparisons
SmartClear II Pro is compatible with many clearing techniques including:

SWITCH (Murray, Cell, 2015)
MAP (Ku, Nature Biotechnology, 2016)
SHIELD (Park, Nature Biotechnology, 2019)

These methods avoid the loss of endogenous fluorescence and tissue shrinkage present in organic solvent-based clearing methods like BABB, iDisco, uDisco, 3DISCO, and vDISCO.

Enjoy batch tissue clearing
while keeping costs low
and samples protected
Multi-Purpose Function
Batch processing and customization: 4 whole mouse brains or 2 rat brains can be cleared simultaneously. Larger clearing chamber enables clearing of various sample types and sizes that can be customized according to your needs.

Cost-Effective Clearing of Bulk Quantity
Cost-effective and Eco-friendly: New-generation buffer set lasts around 10 days without loss of its clearing ability. Lower running costs for samples as the same volume of buffer is used regardless of size and number of samples.

Fast, Easy, and Reliable
Fast and Easy: Order of magnitude faster than passive clearing. Our ready-to-use technologies bring plug-and-play options to clearing.

Stochastic Electrotransport

Reliable: Prevents tissue damage with stochastic electrotransport technology (Kim, PNAS, 2015). Our nanoporous membranes (patent-pending) eliminate tissue contamination, tissue browning, black precipitates and tissue deformation while providing uniform clearing.

Exportable Clearing History and Data

Perfect Clearing with Maximal FP Signal Preservation
FP Signals: Maximum preservation of fluorescent protein (FP) signals with optimized buffers that maintain pH.

Optical Clarity: Minimum light scatter. Removes lipid best for best antibody diffusion. Optimal imaging and staining quality that is compatible with SmartLabel, our rapid staining system for intact samples.